Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Ligands
The receptor is associated with some compounds with a "cheese" or "sour" scent note. Examples of compounds that activate OR51E1 include:
- butyl butyryl lactate
- isovaleric acid
- nonanoic acid
- 3-methylpentanoic acid
- 4-methylpentanoic acid
The following are in decreasing order of activity:
- butyric acid
- methyl eugenol
- methyl salicylate
- ( )-menthol
- eugenyl acetate
- 2,4-dinitrotoluene
- pyrazine
- dimethyl disulfide
- methyl furfuryl disulfide
- pentanol
- propanal
See also
- Olfactory receptor
References
Further reading
External links
- OR51E1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
